Publications

100+ peer-reviewed articles · 8,000+ citations · Top 1% cited scientists worldwide

2025

Remodelling of the gut virome after long-term fasting.

Natalie Falshaw, Quinten R Ducarmon, Alexandra King, Franziska Grundler, Robin Mesnage

medRxiv

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Revisiting the (anti)inflammatory effects of prolonged fasting: the importance of baseline-dependent responses.

Robin Mesnage, Franziska Grundler, Françoise Wilhelmi de Toledo.

Frontier in Nutrition Sec. Nutritional Immunology

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Pesticide contamination in the hair of children from Colonia San Juan, a rural community in Paraguay.

Stela Benitez Leite, Alba Iglesias-Gonzalez, Mirta Noemí Mesquita, María Luisa Macchi, Robin Mesnage, Brice M. R. Appenzeller

Drug Testing and Analysis

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Expected Effects of a Global Transformation of Agricultural Pest Management.

Niklas Möhring, Malick Ba, Anna Braga, Sabrina Gaba, Vesna Gagic, Per Kudsk, Ashley Larsen, Robin Mesnage, Urs Niggli, Matin Qaim, Pepijn Schreinemachers, Christian Stamm, Wim de Vries, Robert Finger.

Nat Commun 16, 10901

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Scientists warning: we must change paradigm for a revolution in toxicology and world food supply.

Gilles-Eric Seralini, Gérald Jungers, Thomas Bohn, Jose Luis Domingo, Jérôme Douzelet, John Fagan, José Luis Yela Garcia, Sophie Gil, Angelika Hilbeck, Lorenz Hilty, Giuseppe Longo, Robin Mesnage, Dimitra Nikolopoulou, Charles Sultan, Brian Wynne.

Environmental Sciences Europe

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Correlation between Early Life Exposure to Regulatory Relevant Doses of Herbicide Mixtures Based on Glyphosate and Development of Liver Dysfunction.

Viorica Dinca, Alaa Mohamad Hbous, Anca Oana Docea, Liliana Cercelaru, Robin Mesnage, Cristina Marginean, Ovidiu Zlatian, Valerii Rakitskii, Radu Mitrut, Michael Antoniou, Aristidis Tsatsakis, Daniela Calina.

Current Health Sciences Journal

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Case report: sustained weight loss and glycemic control from repeated long-term fasting in type 2 diabetes.

Marie Knufinke, Marco Lebbing, Mesnage R

Front. Clin. Diabetes Healthc. Sec. Diabetes Nutrition and Dietetics Volume 6 - 2025

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Long-term fasting-induced parasympathetic and sympathetic autonomic nervous system modulation in a subgroup of the GENESIS study.

Mesnage R, Alfred Holley, Franziska Grundler, Borja Martinez-Tellez, Françoise Wilhelmi de Toledo & Pierre Croisille.

Int J Obes.

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Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague–Dawley rats.

Panzacchi S, Tibaldi E, De Angelis L, Falcioni L, Giovannini R, Gnudi F, Iuliani M, Manservigi M, Manservisi F, Manzoli I, Menghetti I, Montella R, Noferini R, Sgargi D, Strollo V, Truzzi F, Antoniou MN, Chen J, Dinelli G, Lorenzetti S, Mantovani A, Mesnage R, Perry MJ, Vornoli A, Landrigan PJ, Belpoggi F, Mandrioli D.

Environ Health 24(1):36.

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Toxicological concerns regarding glyphosate, its formulations, and co-formulants as environmental pollutants: a review of published studies from 2010 to 2025.

Klátyik S, Simon G, Takács E, Oláh M, Zaller JG, Antoniou MN, Benbrook C, Mesnage R & András S

Arch Toxicol.

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Impact of prolonged fasting on skeletal muscle: delving into the relationship between structure, energy metabolism, and function using 31P/1H MRS and MRI.

Naegel A, Viallon V, Ratiney H, Nguyen T, Leporq B, Kennouche D, Grenier T, Grundler F, Mesnage R, Guy JM, Wilhelmi de Toledo F and Croisille P

In Press in Journal of Cachexia, Sarcopenia and Muscle.

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Comparative analysis of fungal and bacterial composition in natural wines and their closest pesticide-treated counterparts.

Mesnage R, Douzelet J, Seralini GE

Sci Rep. 2025;15(1):4877.

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Environmental Health Is Overlooked in Longevity Research

Mesnage R

Antioxidants 2025, 14(4).

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Long-term fasting induces a remodelling of fatty acid composition in erythrocyte membranes.

Gewecke K, Grundler F, Ruscica M, von Schacky C, Mesnage R, Wilhelmi de Toledo F (2024)

Eur J Clin Invest. 2025; 00:e14382

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2024

Health benefits of a five-day at-home modified fasting program: a randomised controlled trial.

Grundler F, Ducarmon QR, Holley A, Knufinke M, Strathmeyer S, Heelemann S, Geyer R, Tellez BM, MacArthur MR, Zeller G, Wilhelmi de Toledo F, Mesnage R (2024)

MedRxiv 2024.11.01.24316348

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Myths and Facts in the Debates on the Effects of Long-Term Fasting.

Mesnage R (2024)

Insights Into the Therapeutic Applications of Fasting. IntechOpen.

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Impact of long-term fasting on breath volatile sulphur compounds, inflammatory markers and saliva microbiota composition.

Loume A, Grundler F, Wilhelmi de Toledo F, Giannopoulou C, Mesnage R (2024)

Oral Health and Preventive Dentistry. Oct 24:22:525-540.

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Enhanced Labeling to Promote Consumption of Nutrient Dense Foods and Healthier Diets

Benbrook C, Mesnage R

Foods 2024, 13(21), 3377;

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HDL cholesterol efflux capacity and cholesterol loading capacity in long-term fasting: evidence from a prospective, single-arm interventional study in healthy individuals

Grundler F, Palumbo M, Adorni MP, Zimetti F, Papotti B, Plonne D, Holley A, Mesnage R, Ruscica M, Wilhelmi de Toledo F. (2024)

Atherosclerosis. Available online 6 August 2024, 118548

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Long-term fasting remodels gut microbial metabolism and host metabolism

Ducarmon QR, Grundler F, Giannopoulou C, Loumé A, Karcher N, Larralde M, Romano S, MacArthur MR, Mitchell SJ, Wilhelmi de Toledo F, Zeller G, Mesnage R (2024)

bioRxiv 2024.04.19.590209

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Long-Term Fasting-Induced Ketosis in 1610 Subjects: Metabolic Regulation and Safety

Grundler F, Mesnage R, Ruppert PMM, Kouretas D, Wilhelmi de Toledo F. (2024)

Nutrients. 2024 Jun 13;16(12):1849

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Long-term Fasting Promotes Reversible Cardiometabolic Switching: An MR Spectroscopy Study

Rapacchi S, Roussel T, Sourdon J, Ratiney H, Petrusca-Perisanu L, Grundler F, Mesnage R, Wilhelmi De Toledo F, Croisille P, Viallon M. (2024)

Journal of Cardiovascular Magnetic Resonance, 2024, vol. 26.

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The Conflict between Regulatory Agencies over the 20,000-Fold Lowering of the Tolerable Daily Intake (TDI) for Bisphenol A (BPA) by the European Food Safety Authority (EFSA)

Vom Saal FS, Antoniou M, Belcher SM, Bergman A, Bhandari RK, Birnbaum LS, Cohen A, Collins TJ, Demeneix B, Fine AM, Flaws JA, Gayrard V, Goodson WH 3rd, Gore AC, Heindel JJ, Hunt PA, Iguchi T, Kassotis CD, Kortenkamp A, Mesnage R, Muncke J, Myers JP, Nadal A, Newbold RR, Padmanabhan V, Palanza P, Palma Z, Parmigiani S, Patrick L, Prins GS, Rosenfeld CS, Skakkebaek NE, Sonnenschein C, Soto AM, Swan SH, Taylor JA, Toutain PL, von Hippel FA, Welshons WV, Zalko D, Zoeller RT (2024)

Environ Health Perspect. 2024 Apr;132(4):45001

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Ribosomal DNA copy number is associated with body mass in humans and other mammals

Law PP, Rodriguez-Algarra F, Asenius F, Gregori M, Seaborne R, Yildizoglu S, Miller J, Mesnage R, Antoniou MN, Li W, Tan Q, Hillman SL, Rakyan V, Williams DJ, Holland ML (2023)

Nature Communications volume 15, Article number: 5006

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World’s longest medically documented repeated fasting history in a 92 years old man who fasted 21 days yearly for 45 years: a case report

Wilhelmi de Toledo F, Grundler F, Mesnage R (2024)

Journal of Integrative and Complementary Medicine

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(Poly)phenol-related gut metabotypes and human health: an update

Hu J, Mesnage R, Tuohy K, Heiss C, Rodriguez-Mateos A (2024)

Food and Function

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Aquatic ecotoxicity of glyphosate, its formulations, and co-formulants: evidence from 2010 to 2023

Klátyik S, Simon G, Oláh M, Takács E,Mesnage R, Antoniou MN, Zaller J, Székács A (2024)

Environmental Sciences Europe 36:22

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2023

Improvements during long-term fasting in patients with long COVID: a case series and literature review

Grundler F, Mesnage R, Cerrada A, Wilhelmi de Toledo F (2023)

Front. Nutr. Sec. Clinical Nutrition. Volume 10 - 2023

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Remodelling of the intestinal ecosystem during caloric restriction and fasting

Ducarmon Q, Grundler F, Le Maho Y, Wilhelmi de Toledo F, Zeller G, Habold C, Mesnage R (2023)

Trends in Microbiology

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Wild Blueberry (Poly)phenols can Improve Vascular Function And Cognitive Performance In Healthy Older Males And Females: A Double-Blind Randomized Controlled Trial

Wood E, Hein S, Mesnage R, Fernandes F, Abhayaratne N, Xu Y, Zhang Z, Bell L, Williams C, Rodriguez-Mateos A (2023)

The American Journal of Clinical Nutrition

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Effect of perinatal exposure to glyphosate and its mixture with 2,4-D and dicamba on rat dam kidney and thyroid function and offspring's health

Docea A, Cirstea AE, Cercelaru L, Drocas AI, Dinca V, Mesnage R, Marginean C, Radu A, Popa DG, Rogoveanu O, Mitrut R, Antoniou MN, Tsatsakis A, Hernández AF, Calina D (2023)

Environmental Research. Available online 17 August 2023, 116908

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No impacts of glyphosate or Crithidia bombi, or their combination, on the bumblebee microbiome

Straw EA, Mesnage R, Brown MF, Antoniou MN (2023)

Scientific Reports

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Terrestrial ecotoxicity of glyphosate, its formulations, and co-formulants: evidence from 2010–2023

Klátyik S, Simon G, Oláh M, Mesnage R, et al. (2023)

Environ Sci Eur 35, 51

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Evaluation of perinatal exposure of glyphosate and its mixture with 2,4-D and dicamba οn liver redox status in Wistar rats

Nechalioti P, Karampatzakis T, Mesnage R, Antoniou MN, Ibragim M, Tsatsakis A, Docea A, Nepka C, Kouretas D (2023)

Environmental Research 228: 115906

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Comparison of transcriptome alterations induced by pendimethalin or its commercial formulation Stomp Aqua in human MCF-7, MCF-10A and MCF-12A mammary epithelial cells

Mesnage R, Omriouate H, Antoniou MN (2023)

BMC Research Notes 16, 62

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Leveraging the self-healing abilities of our body to promote healthy longevity

Mesnage R, Grundler F, Wilhelmi de Toledo F (2023)

Public Health Toxicology 3(1)

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The GlyphoMix protocol: Multiorgan changes caused by prenatal exposure to glyphosate or its mixture with 2,4-D and dicamba in rats

Mesnage R, Nepka C, Ferguson S, Kouretas D, Stivaktakis PD, Calina D, Tsatsakis A, Antoniou MN, Docea A (2023)

Public Health Toxicology 3(1):7

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Effect of Combination of Lactobacillus acidophilus (Probiotic) with Vitamin K3 and Vitamin E on Escherichia coli and Staphylococcus aureus: in vitro pathogen model

Celebi O, Taghizadehghalehjoughi A, Celebi D, Mesnage R, Golokhvas KS, Arsene AL, Spandidos DA, Tsatsakis A (2023)

Molecular Medicine Reports 27: 119

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Low-Dose Effects of Environmental Chemicals: Bisphenol A as a Case Study

Powell C, Mesnage R, Antoniou MN, Vandenberg LN (2023)

Reference Module in Biomedical Sciences. Encyclopedia of Toxicology, 4th Edition

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Genotoxicity Assays Published since 2016 Shed New Light on the Oncogenic Potential of Glyphosate-Based Herbicides

Benbrook C, Mesnage R, Sawyer W (2023)

Agrochemicals 2(1):47-68

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Reproductive Effects of S. boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats

Sevim Ç, Akpınar E, Aksu EH, Ömür AD, Yıldırım S, Kara M, Bolat İ, Tsatsakis A, Mesnage R, Golokhvast KS, Uzunçakmak SK, Ersoylu RN (2023)

Toxics 11(2):170

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Use of the concept “environmentally relevant level” in linking the results of pesticide toxicity studies to public health outcomes

Mesnage R, Benbrook C (2023)

All Life 16:1

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2022

Cytotoxicity mechanisms of eight major herbicide active ingredients in comparison to their commercial formulations

Ferguson S, Mesnage R, Antoniou M (2022)

Toxics 10(11), 711

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Long-term fasting: multi-system adaptations in humans (GENESIS) study - a single-arm interventional trial

Grundler F, Viallon M, Mesnage R, Ruscica M, von Schacky C, Madeo F, Hofer S, Mitchell S, Croisille P, Wilhelmi de Toledo F (2022)

Front. in Nutrition

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Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome

Mesnage R, Panzacchi P, Bourne E, Mein CA, Perry M, Hu J, Chen J, Mandrioli D, Belpoggi F, Antoniou MN (2022)

Front. Microbiol. 13:888853

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Transcriptome analysis of human mammary epithelial cells treated with bisphenol A and bisphenol A analogue mixtures reveals major alterations in multiple cellular pathways

Mesnage R, Omriouate H, Antoniou MN (2022)

Public Health and Toxicology 2(4):17

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Molecular toxicity study on glyphosate, Roundup MON 52276 and a low-dose pesticide mixture administered to adult Female rats for 90 days

Mesnage R, Antoniou MN (2022)

All Life 15:1, 1273-1275

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The surfactant co-formulant POEA in the glyphosate-based herbicide RangerPro but not glyphosate alone causes necrosis in Caco-2 and HepG2 human cell lines and ER stress in the ToxTracker assay

Mesnage R, Ferguson S, Brandsma I, Moelijker N, Zhang G, Mazzacuva F, Caldwell A, Halket J, Antoniou MN (2022)

Food and Chemical Toxicology. Available online 24 August 2022, 113380

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Glyphosate Exposure in Early Pregnancy and Reduced Fetal Growth: A Prospective Observational Study of High-Risk Pregnancies

Gerona RR, Reiter JL, Proctor C, Ying J, Antoniou M, Mesnage R, Winchester P (2022)

Environ Health 21, Article number: 95

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Microbiome

Mesnage R (2022)

Reference Module in Biomedical Sciences 2022

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Information Resources in Toxicology

Mesnage R, Buha A (2022)

Reference Module in Biomedical Sciences 2022

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Alterations in infant gut microbiome composition and metabolism after exposure to glyphosate and Roundup and/or a spore-based formulation using the SHIME® technology

Mesnage R, Calatayud M, Duysburgh C, Marzorati M, Antoniou M (2022)

Gut Microbiome, 1-30

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Impacts of dietary exposure to pesticides on faecal microbiome metabolism in adult twins

Mesnage R, Bowyer R, El Balkhi S, Saint-Marcoux F, Gardere A, Ducarmon QR, Geelen AR, Zwittink RD, Tsoukalas D, Sarandi E, Paramera EI, Spector T, Steves CJ, Antoniou MN (2022)

Environ Health 21, 46

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Estimation of Redox Status in Military Pilots during Hypoxic Flight-Simulation Conditions—A Pilot Study

Petraki K, Grammatikopoulou MG, Tekos F, Skaperda Z, Orfanou M, Mesnage R, BVassilakou T, Kouretas D (2022)

Antioxidants. 2022; 11(7):1241

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Clinical and Dietary Determinants of Ketosis During Long-Term Fasting in 1610 Subjects

Mesnage R, Grundler F, Ruppert PMM, Wilhelmi de Toledo F(2022)

Current Developments in Nutrition 6 (Supplement_1), 382-382

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Leveraging artificial intelligence to advance the understanding of chemical neurotoxicity

Aschner M, Mesnage R, Docea AO, Paoliello MMB, Tsatsakis A, Giannakakis G, Papadakis GZ, Vinceti SR, Santamaria A, Skalny AV, Tinkov AA (2022)

NeuroToxicology 89:9-11

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Comparative toxicogenomics of glyphosate and Roundup herbicides by mammalian stem cell-based genotoxicity assays and molecular profiling in Sprague-Dawley rats

Mesnage R, Mandrioli D, Falcioni L, Belpoggi F, Brandsma I, Bourne B, Savage E, Mein CA, Antoniou MN (2022)

Toxicological Sciences. Volume 186, Issue 1, Pages 83–101

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2021

Improving pesticide-use data for the EU

Mesnage R, Straw EA, Benbrook C, Brown MJF, Chauzat M, Finger R, Goulson D, Leadbeater E, López-Ballesteros A, Möhring N, Neumann P, Stanley D, Stout JC, Thompson L, Topping CJ, White B, Zaller JG, Zioga E (2021)

Nature Ecology and Evolution. Published: 14/10/2021

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Chronic effects of wild blueberry (poly) phenols on cognitive function in healthy older individuals: the BluFlow study

Hein S, Wood E, Fernandes F, Mesnage R, Rodriguez-Mateos A, Williams C (2021)

Proceedings of the Nutrition Society 80 (OCE2)

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Effects of Daily Wild Blueberry Consumption on Cognitive and Vascular Function in Healthy Older Individuals: A Randomized Double Blind Controlled Trial (the Bluflow Study)

Hein S, Wood E, Abhayaratne N, Mesnage R, Fernandes F, Williams C, Rodriguez-Mateos A (2021)

Current Developments in Nutrition, Volume 5, Issue Supplement_2, Page 318

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Genotoxicity evaluation of 2,4-D, dicamba and glyphosate alone or in combination with cell reporter assays for DNA damage, oxidative stress and unfolded protein response

Mesnage R, Brandsma B, Moelijker N, Zhang G, Antoniou MN (2021)

Food Chem Toxicol. 2021 Oct 6;157:112601

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Alterations in small RNA profiles in liver following a subchronic exposure to a low-dose pesticide mixture in Sprague-Dawley rats

Mesnage R, Mahmud N, Mein CA, Antoniou MN (2021)

Toxicol Lett. 2021 Oct 6:S0378-4274(21)00848-1

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Excretion of heavy metals and glyphosate in urine and hair before and after long-term fasting in humans

Grundler F, Mesnage R, Séralini GE, Peynet V, Wilhelmi de Toledo F (2021)

Front. Nutr. 8:708069

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Commentary: Novel strategies and new tools to curtail the health effects of pesticides

Benbrook C, Perry MJ, Belpoggi F, Landrigan PJ, Perro M, Mandrioli D, Antoniou MN, Winchester P, Mesnage R (2021)

Environ Health 20, 87

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Long-term fasting improves lipoprotein-associated atherogenic risk in humans

Grundler R, Plonné D, Mesnage R, Müller D, Sirtori CR, Ruscica M, Wilhelmi de Toledo F (2021)

European Journal of Nutrition

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Multi-omics phenotyping of the gut-liver axis reveals metabolic perturbations from a low-dose pesticide mixture in Sprague-Dawley rats

Mesnage R, Teixeira M, Mandrioli D, Falcioni L, Ducarmon QR, Zwittink RD, Amiel C, Panoff J, Bourne B, Savage E, Mein CA, Belpoggi F, Antoniou MN (2021)

Communications Biology 4, 471

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Use of shotgun metagenomics and metabolomics to evaluate the impact of glyphosate or Roundup MON 52276 on the gut microbiota and serum metabolome of Sprague-Dawley rats

Mesnage R, Teixeira M, Mandrioli D, Falcioni L, Ducarmon QR, Zwittink RD, Mazzacuva F, Caldwell A, Halket J, Amiel C, Panoff J, Belpoggi F, Antoniou MN (2021)

Environmental Health Perspectives. Jan;129(1):17005

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Analytical strategies to study the gut microbiome in toxicology

Mesnage R and Antoniou MN (2021)

In Tsatsakis A ed. Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. Elsevier

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Redox Biomarker Baseline Levels in Cattle Tissues and Their Association with Meat Quality

Skaperda Z, Argyriadou A, Nechalioti P, Alvanou M, Makria S, Bouroutzika E, Kyriazis ID, Tekos F, Veskoukis AS, Kallitsis T, Mesnage R, Arsenos G, Kouretas D (2021)

Antioxidants. 10(6), 958

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Urinary excretion of herbicide co-formulants after oral exposure to Roundup MON 52276 in rats

Mesnage R, Mazzacuva F, Caldwell A, Halket J, Antoniou MN (2021)

Environmental Research. Available online 1 April 2021

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Impacts of a glyphosate-based herbicide on the gut microbiome of three earthworm species (Alma millsoni, Eudrilus eugeniae and Libyodrilus violaceus): a pilot study

Owagboriaye F, Mesnage R, Dedeke G, Adegboyega T, Aladesida A, Adeleke M, Owa S, Antoniou MN (2021)

Toxicology Reports. Available online 31 March 2021

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Herbicides: Chemistry, Efficacy, Toxicology, and Environmental Impacts

Mesnage R, Zaller JG (2021)

Emerging Issues in Analytical Chemistry. Cambridge, MA: Elsevier in cooperation with RTI Press

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Herbicides: Brief history, agricultural use, and potential alternatives for weed control

Mesnage R, Székács A, Zaller JG (2021)

In Mesnage R, Zaller JG, eds. Herbicides: Chemistry, Efficacy, Toxicology, and Environmental Impacts. Elsevier in cooperation with RTI Press

Co-formulants in commercial herbicides

Mesnage R (2021)

In Mesnage R, Zaller JG, eds. Herbicides: Chemistry, Efficacy, Toxicology, and Environmental Impacts. Elsevier in cooperation with RTI Press

Human health effects of herbicides used in intensive GM crop farming

Mesnage R, Antoniou MN (2021)

In Mesnage R, Zaller JG, eds. Herbicides: Chemistry, Efficacy, Toxicology, and Environmental Impacts. Elsevier in cooperation with RTI Press

Analytical strategies to measure health effects of herbicides: predictive toxicology

Mesnage R (2021)

In Mesnage R, Zaller JG, eds. Herbicides: Chemistry, Efficacy, Toxicology, and Environmental Impacts. Elsevier in cooperation with RTI Press

Herbicides: a necessary evil? An integrative overview

Mesnage R, Zaller JG (2021)

In Mesnage R, Zaller JG, eds. Herbicides: Chemistry, Efficacy, Toxicology, and Environmental Impacts. Elsevier in cooperation with RTI Press

2020

Blood pressure changes in 1610 subjects with and without antihypertensive medication during long-term fasting

Grundler F, Mesnage R, Michaelsen A, Wilhelmi de Toledo F (2020)

Journal of the American Heart Association. Published 23 Nov 2020

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Interplay between oxidative damage, the redox status, and metabolic biomarkers during long-term fasting

Grundler F, Mesnage R, Goutzourelas N, Tekos F, Makri S, Brack M, Kouretas D, Wilhelmi de Toledo F (2020)

Food and Chemical Toxicology

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Influence of Long-Term Fasting on Blood Redox Status in Humans

Wilhelmi de Toledo F, Grundler F, Goutzourelas N, Tekos F, Vassi E, Mesnage R, Kouretas D (2020)

Antioxidants. 9(6), 496

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Computational modelling provides insight into the effects of glyphosate on the shikimate pathway in the human gut microbiome

Mesnage R, Antoniou M (2020)

Current Research in Toxicology

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Achieving a High Level of Protection from Pesticides in Europe: Problems with the Current Risk Assessment Procedure and Solutions

Robinson C, Portier CJ, Čavoski A, Mesnage R, Roger A, Clausing P, Whaley P, Muilerman H, Lyssimachou A (2020)

European Journal of Risk Regulation, 1-31

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Chronic inflammation in the context of everyday life - dietary changes as mitigating factors

Marginǎ D, Ungurianu A, Purdel C, Tsoukalas D, Sarandi A, Thanasoula M, Tekos F, Kouretas D, Mesnage R, Tsatsakis A (2020)

International Journal of Environmental Research and Public Health. Article 814023

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Transcriptome profiling of the fungus Aspergillus nidulans exposed to a commercial glyphosate-based herbicide under conditions of apparent herbicide tolerance

Mesnage R, Oestreicher N, Poirier F, Nicolas V, Boursier C, Vélot C (2020)

Environmental Research. Available online 7 January 2020, 109116

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Limitations in the evidential basis supporting health benefits from a decreased exposure to pesticides through organic food consumption

Mesnage R, Tsakiris IN, Antoniou MN, Tsakiris A (2020)

Current Opinion in Toxicology

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2019

Changes in Human Gut Microbiota Composition Are Linked to the Energy Metabolic Switch During Ten Days of Fasting

Mesnage R, Grundler F, Schwiertz A, Le Maho Y, Wilhelmi de Toledo F (2019)

Journal of Nutritional Science 8

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Quizalofop-p-ethyl induces adipogenesis in 3T3-L1 adipocytes

Biserni M, Mesnage R, Wozniak E, Xenakis T, Mein CA, Antoniou MN (2019)

Toxicological Sciences, kfz097

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Effects of single and combined toxic exposures on the gut microbiome: current knowledge and future directions

Tsiaoussis J., Antoniou MN, Koliarakis I, Mesnage R, Vardavas CI, Izotov BN., Psaroulaki A,, Tsatsakis AM (2019)

Toxicology Letters. Accepted 11 Apr 2019

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Relationship between faecal microbiota and plasma metabolome in rats fed NK603 and MON810 GM maize from the GMO90+ study

Mesnage R, Le Roy C, Biserni M, Salles B, Antoniou MN (2019)

Food Chem Toxicol. 2019 Jun 3;131:110547

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Insight into the confusion over surfactant co-formulants in glyphosate-based herbicides

Mesnage R, Benbrook C, Antoniou MN (2019)

Food Chem Toxicol

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Gut microbiome metagenomics to understand how xenobiotics impact human health

Mesnage R, Antoniou MN, Tsoukalas D, Goulielmos GN, Tsatsakis AM (2019)

Current Opinion in Toxicology. 11-12:51–58

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Overview of the effects of chemical mixtures with endocrine disrupting activity in the context of real‑life risk simulation (RLRS): An integrative approach

Margina D, Mihai G, Ungurianu A, Mesnage R, Goumenou M, Sarigiannis DA, Aschner M, Spandidos DA, Renieri EA, Hernández AF, Tsatsakis A (2019)

World Academy of Sciences Journal

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Glyphosate does not substitute for glycine in proteins of actively dividing mammalian cells

Antoniou MN, Nicolas A, Mesnage R, Biserni M, Rao FV, Vasquez Martin C (2019)

BMC Research Notes. volume 12, Article number: 494

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2018

Addressing concerns over the fate of DNA derived from genetically modified food in the human body: A review

Nawaz MA, Mesnage R, Tsatsakis AM, Golokhvast KS, Yang SH, Antoniou MN, Chung G (2018)

Food Chem Toxicol. 2018 Dec 21;124:423-430

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An imazamox-based herbicide causes apoptotic changes in rat liver and pancreas

Sevim Ç, Çomaklı S, Taghizadehghalehjoughi A, Özkaraca M, Mesnage R, Kovatsi L, Burykina TI, Kalogeraki A, Antoniou MN, Tsatsakis A (2018)

Toxicol Rep. 2018 Nov 19;6:42-50

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Multidisciplinary approaches to evaluate pesticide effects on health and environment

Mesnage R, Séralini GE (2018)

Frontiers in Public Health 6, 268

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Call to restrict neonicotinoids

Goulson et al., 232 signatories (2018)

Science, 360(6392), 973.1–973

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Comparison of transcriptome responses to glyphosate, isoxaflutole, quizalofop-p-ethyl and mesotrione in the HepaRG cell line

Mesnage R, Biserni M, Wozniak E, Xenakis T, Mein CA, Antoniou MN (2018)

Toxicology reports 5, 819-826

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Evaluation of neonicotinoid insecticides for oestrogenic, thyroidogenic and adipogenic activity reveals imidacloprid causes lipid accumulation

Mesnage R, Biserni M, Genkova D, Wesolowski L, Antoniou MN (2018)

J Appl Toxicol. 1–9

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Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126

Mesnage R, Biserni M, Balu S, Frainay C, Poupin N, Jourdan F, Wozniak E, Xenakis T, Mein CA, Antoniou MN (2018)

Archives of Toxicology, 1-15

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Ignoring Adjuvant Toxicity Falsifies the Safety Profile of Commercial Pesticides

Mesnage R, Antoniou MN (2018)

Front Public Health. 2018 Jan 22;5:361

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2017

Sex-dependent impact of Roundup on the rat gut microbiome

Lozano VL, Defarge N, Rocque LM, Mesnage R, Hennequin D, Cassier R, de Vendômois JS, Panoff JM, Séralini GE, Amiel C (2017)

Toxicol Rep. Dec 19;5:96-107

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Facts and Fallacies in the Debate on Glyphosate Toxicity

Mesnage R, Antoniou MN (2017)

Front Public Health. Nov 24;5:316

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Proteomic analysis of the soil filamentous fungus Aspergillus nidulans exposed to a Roundup formulation at a dose causing no macroscopic effect: a functional study

Poirier F, Boursier C, Mesnage R, Oestreicher N, Nicolas V, Vélot C (2017)

Environ Sci Pollut Res Int. 2017 Nov;24(33):25933-25946

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Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents

Mesnage R, Phedonos A, Biserni M, Arno M, Balu S, Christopher Corton J, Ugarte R, Antoniou MN (2017)

Food and Chemical Toxicology

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Roundup Ready! Glyphosate and the Current Controversy Over the World’s Leading Herbicide

Mesnage R, Antoniou MN (2017)

In book: Encyclopedia of the Anthropocene – Reference Module in Earth Systems and Environmental Sciences

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Is it time to reassess current safety standards for glyphosate-based herbicides?

Vandenberg LN, Blumberg B, Antoniou MN, Benbrook CM, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Lanphear BP, Mesnage R, Vom Saal FS, Welshons WV, Myers JP (2017)

J Epidemiol Community Health. 71(6):613-618

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Transcriptome profiling reveals bisphenol A alternatives activate estrogen receptor alpha in human breast cancer cells

Mesnage R, Phedonos A, Arno M, Balu S, Christopher Corton J, Antoniou MN (2017)

Toxicol Sci. 2017 158(2):431-443

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Transcriptome and metabolome analysis of liver and kidneys of rats chronically fed NK603 Roundup-tolerant genetically modified maize

Mesnage R, Arno M, Séralini GE, Antoniou M (2017)

Environmental Sciences Europe. 29:6

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Multiomics reveal non-alcoholic fatty liver disease in rats following chronic exposure to an ultra-low dose of Roundup herbicide

Mesnage R, Renney G, Séralini GE, Ward M, Antoniou M (2017)

Scientific Reports. 6, 39328

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2016

An integrated multi-omics analysis of the NK603 Roundup-tolerant GM maize reveals metabolism disturbances caused by the transformation process

Mesnage R, Agapito-Tenfen S, Vilperte V, Renney G, Ward M, Séralini GE, Nodari N, Antoniou M (2016)

Scientific Reports. 6, 37855

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Development and validation of a custom microarray for global transcriptome profiling of the fungus Aspergillus nidulans

Deloménie C., Grentzmann G., Oestreicher N., Mesnage R, Vélot C (2016)

Current Genetics. 62(4):897-910

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Co-formulants in glyphosate-based herbicides disrupt aromatase activity in human cells below toxic levels

Defarge N., Takács E., Lozano V., Mesnage R, Spiroux De Vendômois J., Séralini GE., Székács A (2016)

Int J Environ Res Public Health. 13(3). pii: E264

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Concerns over use of glyphosate-based herbicides and risks associated with exposures: a consensus statement

Myers JP, Antoniou MN, Blumberg B, Carroll L, Colborn T, Everett LG, Hansen M, Landrigan PJ, Lanphear BP, Mesnage R, Vendenberg LN, vom Saal FS, Welshons WV, Benbrook CM (2016)

Environ Health. 15:19

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2015

Transcriptome profile analysis reflects rat liver and kidney damage following chronic ultra-low dose Roundup exposure

Mesnage R, Arno M, Costanzo M, Malatesta M, Séralini GE, Antoniou MN (2015)

Environ Health. 14(1):70

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Potential toxic effects of glyphosate and its commercial formulations below regulatory limits

Mesnage R, Defarge N, Spiroux de Vendômois J, Séralini GE (2015)

Food Chem Toxicol. 84:133-53

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Laboratory Rodent Diets Contain Toxic Levels of Environmental Contaminants: Implications for Regulatory Tests

Mesnage R, Defarge N, Rocque LM, Spiroux de Vendômois J, Séralini GE (2015)

PLoS One. 10(7):e0128429

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2014

Letter to the Editor regarding “Delaney et al., 2014”: Uncontrolled GMOs and their associated pesticides make the conclusions unreliable

Mesnage R, Defarge N, Spiroux de Vendômois J.and Séralini G.-E. (2014)

Food Chem Toxicol

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The need of a closer look for pesticide toxicity during GMO assessment

Mesnage R, Séralini G.E. (2014)

Chapter 10 in Practical Food Safety: Contemporary Issues and Future Directions, First Edition. Edited by Rajeev Bhat and Vicente M. Gómez-López. John Wiley & Sons, Ltd

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Conflicts of interests, confidentiality and censorship in health risk assessment: The example of an herbicide and a GMO

Séralini G.E., Mesnage R, Defarge N., and Spiroux de Vendômois J. (2014)

Environmental Sciences Europe 26:14

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Republished study: Long-term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize

Séralini G.E., Clair E., Mesnage R, Gress S., Defarge N., Malatesta M., Hennequin D. and Spiroux de Vendômois J. (2014)

Environmental Sciences Europe 26:13

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Conclusiveness of toxicity data and double standards

Séralini G.E., Mesnage R, Defarge N., and Spiroux de Vendômois J. (2014)

Food Chem Toxicol. 69: 357–359

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Major pesticides are more toxic to human cells than their declared active principles

Mesnage R, Defarge N., Spiroux de Vendômois J.and Séralini G.-E. (2014)

BioMed Research International. Vol 2014, Article ID 179691

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2013

Answers to critics : Why there is a long term toxicity due to NK603 Roundup-tolerant genetically modified maize and to a Roundup herbicide

Séralini G.E., Mesnage R, Defarge N., Gress S., Hennequin D., Clair E., Malatesta M., and Spiroux de Vendômois J. (2013)

Food and Chemical Toxicology.53: 461-8

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Ethoxylated adjuvants of glyphosate-based herbicides are active principles of human cell toxicity

Mesnage R, Bernay B., Séralini G.E. (2013)

Toxicology 16; 313(2-3):122-8

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Cytotoxicity on human cells of Cry1Ab and Cry1Ac Bt insecticidal toxins alone or with a glyphosate-based herbicide

Mesnage R, Clair E., Gress S., Then C., Szekacs A. and Séralini G.-E. (2013)

Journal of Applied Toxicology 7:695-9

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Human cell toxicity of pesticides associated to wide scale agricultural GMOs

Mesnage R, Gress S., Defarge N., and Séralini G.-E. (2013)

Theorie in der Ökologie, 7:118-20

2012

A glyphosate-based herbicide induces necrosis and apoptosis in mature rat testicular cells in vitro, and testosterone decrease at lower levels

Clair E., Mesnage R, Travert C., Séralini G.E. (2012)

Toxicology in vitro. 26(2): 269-79

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Endocrine Disruptors “New discoveries and possible progress of evaluation”

Benachour N., Clair E., Mesnage R, Séralini G.-E. (2012)

Chapter in “Advances in Medicine and Biology, Volume 29” Nova Science Publishers

Glyphosate exposure in a farmer’s family

Mesnage R, Moesch C., Le Grand R., Lauthier G., Spiroux de vendômois J., Gress. S. and Séralini G.E (2012)

Journal of Environmental Protection. 3(9): 1001-1003

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Letter to the editor: developmental and reproductive outcomes of roundup and glyphosate in humans and animals

Defarge N., Mesnage R, Gress S., Séralini G.E. (2012)

J Toxicol Environ Health B Crit Rev. 15(7): 433-40

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2011

Genetically Modified Crops Safety Assessments: Present Limits and Possible Improvements

Séralini G.-E., Mesnage R, Clair E., Gress S., Cellier D., Spiroux de Vendômois J.(2011)

Environmental Sciences Europe 23:10

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Defined plant extracts can protect human cells against combined xenobiotic effects

Gasnier C., Laurent C., Mesnage R, Clair E., Séralini G.E (2011)

Journal of Occupational Medicine and Toxicology 6:3

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2010

Roundup in Genetically modified crops: Regulation and toxicity in mammals

Mesnage R, Clair E., Séralini G.-E. (2010)

Theorie in der Ökologie 16:31-33

Genetically modified crop consumption at large scale: Possible negative health impacts due to holes in assessment. Overview of the safety studies of GMOs performed on mammals

Séralini G.E., Spiroux de Vendomois J., Cellier D., Mesnage R, Clair E. (2010)

Theorie in der Ökologie 16:28-30

Un herbicide à base de glyphosate induit la nécrose et l’apoptose des cellules testiculaires de rats matures

Clair E., Mesnage R, Gress S., Travert C., Séralini G.E. (2010)

Annales d’Endocrinologie 71 340–353

Two cases of birth defects overlapping Stratton-Parker syndrome after multiple pesticide exposure

Mesnage R, Clair E., Spiroux de Vendômois J., Séralini G.E. (2010)

Occup Environ Med 67:359

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Debate on GMOs Health Risks After Statistical Findings in Regulatory Tests

Spiroux de Vendomois J., Cellier D., Vélot C., Clair E., Mesnage R, Séralini G.E. (2010)

Int. J. Biol. Sci. 6(6):590-598

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